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IMMUNOTHERAPY

NIVOLUMAB FOR NPC: IMMUNOTHERAPY ACTIVE IN NASOPHARYNGEAL CARCINOMA (NCI-9742)

Medical writer: Stijn van den Borne, MSc | On: 31st March 2018 | In: Head and Neck Cancer, ImmunoOncology, Immunotherapy, Oncology

Article Keywords

BMS, Bristol-Myers Squibb, Nasopharyngeal Carcinoma, nasopharynx, nivolumab, NPC, Oncology News, Opdivo, PD-1

Nivolumab in patients with recurrent or metastatic nasopharyngeal carcinoma (NPC) was associated with a 1-year overall survival (OS) rate of 59% (95% CI, 44.3-78.5) which compares favorably with historic results. This was concluded by the investigators of the collaborative Phase II NCI-9742 study conducted in Hong Kong, Singapore and the United States (US).

Comparative data in similar populations have consistently reported 1-year OS rates of ~45% for both cytotoxic and non-cytotoxic drugs. A recently published Phase Ib study in 27 treatment-naïve or pretreated squamous and non-squamous NPC patients resulted in a 1-year OS rate of 63%.

The study recruited 44 treatment-refractory patients with loco-regional or distant recurrences and who were not amenable to curative treatment. Most participants (82.2%) were of Asian ancestry with histologically or cytologically confirmed NPC. Over 80% of subjects were found to have non-keratinizing NPC, which is reflective of endemic NPC. The median age was 57.0 (37.0-76.0) years. Almost all subjects had detectable plasma EBV-DNA at baseline.

Participants in the NCI-9742 study received 3 mg/kg of nivolumab every two weeks on a 4-week cycle until progression disease. The median duration of treatment was 3 (1-19) cycles. For the 28 patients still alive at the data cut-off, the median follow-up was 12.5 (2.2-22.0) months.

Figure 1. Response rates with nivolumab in advanced nasopharyngeal carcinoma (NPC) in the NCI-9742 study

    Key Results

    Nivolumab in patients with recurrent or metastatic nasopharyngeal carcinoma (NPC) was associated with a 1-year OS rate of 59% (95% CI, 44.3-78.5). The median overall survival (OS) was 17.1 months (95% CI, 10.9–not reached), with an overall response rate (ORR) of 20.5% (Figure 1). The disease control rate was 54.5%, the 1-year PFS-rate was 19.3% (95% CI, 10.1-37.2) and the median progression-free survival (PFS) was 2.8 months (95% CI, 1.8-7.4).

    Translational research component

    The study included a pre-planned biomarker study. Archived, paraffin-embedded NPC samples were successfully collected from 42 participants. Plasma samples were collected from 43 subjects. No statistical difference in OS or PFS was observed between patients considered PD-L1–negative (PD-L1 expression <1%; N=24) vs PD-L1–positive patients (PD-L1 expression ≥1%; N=18).

    PD-L1 expression

    Six (33%) patients with PD-L1–positive NPC responded to nivolumab vs three (13%) patients with PD-L1–negative NPC (not significant). Previously, the group presented incomplete data in 21 patients during the American Association for Cancer Research (AACR) Annual Meeting 2017 summarising the response rates by PD-L1 expression (Table 1).


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    Table 1. Response rates by PD-L1 expression (partial data) in 21 participants of the NCI-9742 study with nivolumab in nasopharyngeal carcinoma (NPC) as presented during the AACR Annual Meeting 2017
    PD-L1 ExpressionProgression Disease (%)Stable Disease (%)Partial Response (%)
    No PD-L1 expression11–
    Less than 1%62–
    5%–42
    10%1––
    20%–1–
    30%–11
    80%––1

    HLA expression

    Forty-one samples could be stained for human leukocyte antigen (HLA) A and B expression, and the survival and response rates are reported in Table 2. There was a statistical difference in the 1-year PFS-rate and median PFS between NPC patients whose cancers showed loss of expression of HLA-A and/or HLA-B. The difference in the 1-year OS rate was non-significant, and the difference in median OS was not yet evaluable. Finally, the response rates did not show a statistical difference.

    Table 2. Survival and responses in patients with loss of HLA-A and/or B expression vs patients with HLA-A and B expression in the NCI-9742 study of nivolumab in nasopharyngeal carcinoma (NPC)
    MeasurementSubjects with loss of HLA-A and/or B expressionSubjects with HLA-A and B expressionStatistical Assessment
    1-year PFS rate30.9%5.6%Reached significance
    Median PFS4.8 months1.8 monthsReached significance
    1-year OS rate 75.7%33.8%Not significant
    Median OSNot reached10.9 monthsNot evaluable
    Response rate19.2%22.2%Not significant

    Adverse events

    Most patients permanently discontinued treatment because of disease progression (69.2%). Approximately 10% of patients discontinued treatment because of toxicities.

    Forty-five patients were evaluable for AEs. Most toxicities were according to the nivolumab US FDA approved package insert (USPI). Ten (22.2%) subjects experienced grade ≥3 AEs, including colitis, diarrhoea, fatigue, increase in aspartate transaminase (AST) or alanine aminotransferase levels (ALT), neutropenia, hyponatremia, and lymphopenia. During treatment, one patient died of pulmonary tuberculosis.

    Citations

    Ma BBY et al. J Clin Oncol. Published online March 27, 2018. doi: 10.1200/JCO.2017.77.0388.

    Ma BBY et al. Cancer Res 2017;77(13 Suppl):Abstract nr CT076. doi: 10.1158/1538-7445.AM2017-CT076.

    Disclaimer

    This article is not medical advice. Patients should seek personal assessment by a licenced specialist. Physicians are recommended to read the full publication(s) as cited in the article before making medical decisions. This article does not supersede nor replace the published article(s).

    © Copyright 2018 MediPaper Medical Communications Ltd. – Immunotherapy & ImmunoOncology (I-O) Nivolumab NPC Opdivo Nasopharyngeal Carcinoma Brigette Ma CUHK Phase II NCI-9742 study JCO Journal of Clinical Oncology 2018

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    https://ftp.medi-paper.com/wp-content/uploads/2020/12/asco-guidelines-for-the-use-of-systemic-therapies-in-advanced-hepatocellular-cancer.jpg 1024 1819 Kirsty LEE https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Kirsty LEE2020-12-07 17:20:022020-12-11 14:24:21ASCO Guidelines for the Use of Systemic Therapies in Advanced Hepatocellular Cancer
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    https://ftp.medi-paper.com/wp-content/uploads/2020/09/Evidence-of-SARS-CoV2-in-heart-cells.jpg 1024 1819 Kirsty LEE https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Kirsty LEE2020-09-22 10:19:272020-09-24 12:33:04Evidence of SARS-CoV2 in heart cells
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    paclitaxel, cobimetinib, Cotellic, MEK, Exelixis, atezolizumab, Tecentriq, nab-paclitaxel pembrolizumab, Keytruda, Merck, MSD, eribulin mesylate, Halaven, pertuzumab, trastuzumab, Herceptin, Perjeta, docetaxel, Taxotere, Sanofi, trastuzumab-dkst, Ogivri, Mylan, Biocon, margetuximab, MacroGenics, capecitabine, Xeloda, Genentech, gemcitabine, Gemzar, vinolrebine, pyrotinib, Jiangsu HengRui Medicine, neratinib, Nerlynx, Puma, lapatinib, Tykerb, carboplatin, T-DM1, ado-trastuzumab emtansine, Kadcyla doxorubicin, cisplatin, olaparib, Lynparza, cyclophosphamide, epirubicin, Ellence, Pharmorubicin, letrozole, Femara, Novartis, AI, NSAI, capivasertib, capivasertib, AZD5363, AKT, hormonal therapy, endocrine therapy, CDK4/6, RAD001, mTOR, fulvestrant, Faslodex, abemaciclib, Verzenio, Eli Lilly, ribociclib, Kisqali, goserilin, Zoladex, AstraZeneca, everolimus, Afinitor, exemestane, Aromasin, Pfizer, palbociclib, Ibrance, #ASCO2019, AKT1, AZ, BRCA, chemotherapy, CNS metastases, ER-positive, ESR1, GnRH, HER2-negative, HER2-positive, HR-positive, LABC, neoadjuvant, OfS, PARP, PARPi, pCR, PD-L1, postmenopausal, PR-positive, premenopausal, RB1, TAC, taxane, TNBC, trastuzumab, triptorelin

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    Venetoclax FDA approved for CLL and SLL

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    FDA approves avelumab plus axitinib for renal cell carcinoma

    https://ftp.medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-05-14 16:22:572019-05-22 22:49:14FDA approves avelumab plus axitinib for renal cell carcinoma

    Ramucirumab FDA approved for hepatocellular carcinoma

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    T-DM1 FDA approved for early breast cancer

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    Ivosidenib FDA-approved as first-line treatment for AML patients with IDH1 mutation

    https://ftp.medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2019-05-02 16:25:032019-05-22 22:14:36Ivosidenib FDA-approved as first-line treatment for AML patients with IDH1 mutation
    Can a novel, temporary, and fully resorbable surgical implant improve the outcome of common hockey and soccer injuries?

    Can a novel, temporary, and fully resorbable surgical implant improve the outcome of common hockey and soccer injuries?

    https://ftp.medi-paper.com/wp-content/uploads/2019/04/Can-a-novel-temporary-and-fully-resorbable-surgical-implant-improve-the-outcome-of-common-hockey-and-soccer-injuries.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-04-26 20:05:262019-04-26 20:12:32Can a novel, temporary, and fully resorbable surgical implant improve the outcome of common hockey and soccer injuries?

    Pembrolizumab plus axitinib FDA approved for the first-line treatment of advanced renal cell carcinoma patients

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    KEYNOTE-158 pembrolizumab in previously treated advanced cervical cancer

    KEYNOTE-158: pembrolizumab in previously treated advanced cervical cancer

    https://ftp.medi-paper.com/wp-content/uploads/2019/04/KEYNOTE-158-pembrolizumab-in-previously-treated-advanced-cervical-cancer.jpg 844 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-04-24 18:22:142019-04-24 18:22:14KEYNOTE-158: pembrolizumab in previously treated advanced cervical cancer
    Atezolizumab with or without cobimetinib vs regorafenib for previously treated metastatic colorectal cancer IMblaze370

    Atezolizumab +/- cobimetinib vs regorafenib for previously treated metastatic colorectal cancer (IMblaze370)

    https://ftp.medi-paper.com/wp-content/uploads/2019/04/Atezolizumab-with-or-without-cobimetinib-vs-regorafenib-for-previously-treated-metastatic-colorectal-cancer-IMblaze370.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-04-22 21:21:372019-04-22 21:57:04Atezolizumab +/- cobimetinib vs regorafenib for previously treated metastatic colorectal cancer (IMblaze370)

    Palbociclib approved for the treatment of male breast cancer 

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    Erdafitinib FDA approved for the treatment of metastatic urothelial carcinoma

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    Atezolizumab FDA approved for extensive-stage small cell lung cancer (SCLC)

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    Atezolizumab FDA approved for PD-L1 positive unresectable triple-negative breast cancer

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    Immunoncology I-O drugs and immunotherapy for renal cancer RCC

    Combinations: upcoming treatment strategies in metastatic renal cell carcinoma

    https://ftp.medi-paper.com/wp-content/uploads/2019/02/Immunoncology-I-O-drugs-and-immunotherapy-for-renal-cancer-RCC-.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-03-05 11:13:432019-03-07 14:27:09Combinations: upcoming treatment strategies in metastatic renal cell carcinoma

    Trifluridine/tipiracil combination FDA approved for metastatic gastric or GEJ adenocarcinoma

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    Pembrolizumab FDA approved for adjuvant treatment of melanoma

    https://ftp.medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2019-02-16 14:55:172019-03-07 14:56:16Pembrolizumab FDA approved for adjuvant treatment of melanoma

    Trastuzumab-biosimilar Ontruzant® FDA approved in several indications

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    ERAS guidelines for antenatal and preoperative care in caesarean delivery 1

    ERAS guidelines for antenatal and preoperative care in caesarean delivery

    https://ftp.medi-paper.com/wp-content/uploads/2019/01/ERAS-guidelines-for-antenatal-and-preoperative-care-in-caesarean-delivery-1.jpg 814 1500 Anaesthesiology.asia https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Anaesthesiology.asia2019-01-21 13:54:592019-01-21 22:02:18ERAS guidelines for antenatal and preoperative care in caesarean delivery

    Cabozantinib FDA approved in HCC patients failing sorafenib

    https://ftp.medi-paper.com/wp-content/uploads/2018/11/FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2019-01-17 10:35:362019-02-18 13:23:29Cabozantinib FDA approved in HCC patients failing sorafenib
    Erasmus University MC investigating a new surgical matrix to reduce post-operative complications

    Erasmus University MC investigating a new surgical matrix to reduce post-operative complications

    https://ftp.medi-paper.com/wp-content/uploads/2019/01/Erasmus-University-MC-investigating-a-new-surgical-matrix-to-reduce-post-operative-complications.jpg 900 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-01-16 22:58:582019-01-16 23:09:21Erasmus University MC investigating a new surgical matrix to reduce post-operative complications

    Keytruda® FDA approved for recurrent and metastatic Merkel cell carcinoma

    https://ftp.medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2019-01-14 15:36:172019-01-14 15:43:55Keytruda® FDA approved for recurrent and metastatic Merkel cell carcinoma

    Calaspargase pegol-mknl (Asparlas®) FDA approved in paediatric and young adult acute lymphoblastic leukaemia (ALL) patients

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    Elzonris™ FDA approved for blastic plasmacytoid dendritic cell neoplasm (BPDCN)

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    Dr Paul Kessler - Euroanaesthesia 2018 - Awake, Sedated or Anaesthetised for Regional Anaesthesia Block Placements©Aspen Pharmacare

    Awake, Sedated or Anaesthetised for Regional Anaesthesia Block Placements

    https://ftp.medi-paper.com/wp-content/uploads/2018/12/Dr-Paul-Kessler-Euroanaesthesia-2018-Awake-Sedated-or-Anaesthetised-for-Regional-Anaesthesia-Block-Placements.png 539 800 Anaesthesiology.asia https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Anaesthesiology.asia2018-12-26 16:49:292019-01-23 13:34:18Awake, Sedated or Anaesthetised for Regional Anaesthesia Block Placements
    Dr Ngai LIU - Euroanaesthesia 2018 - Closed-Loop or Automated Titration of IV Anaesthesia Impact on Routine Anaesthesia©Aspen Pharmacare

    Closed-Loop or Automated Titration of IV Anaesthesia: Impact on Routine Anaesthesia

    https://ftp.medi-paper.com/wp-content/uploads/2018/12/Dr-Ngai-LIU-Euroanaesthesia-2018-Closed-Loop-or-Automated-Titration-of-IV-Anaesthesia-Impact-on-Routine-Anaesthesia-e1548221779756.png 444 800 Anaesthesiology.asia https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Anaesthesiology.asia2018-12-25 00:45:102019-01-23 13:33:53Closed-Loop or Automated Titration of IV Anaesthesia: Impact on Routine Anaesthesia

    Olaparib (Lynparza) FDA approved as maintenance for BRCAm ovarian cancer

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    Trastuzumab-biosimilar Herzuma® FDA approved in HER2+ breast cancer

    https://ftp.medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-12-21 15:19:112018-12-21 15:32:40Trastuzumab-biosimilar Herzuma® FDA approved in HER2+ breast cancer

    Frontline atezolizumab plus bevacizumab and chemotherapy FDA approved for metastatic non-squamous NSCLC

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    MURANO: off-drug progression-free survival after 2 years venetoclax plus 6 cycles Rituximab

    MURANO: off-drug progression-free survival after 2 years venetoclax plus 6 cycles Rituximab

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    TIGR®Matrix shows promising results when used for incisional hernia prevention in septic patients undergoing laparoscopy

    TIGR®Matrix shows promising results when used for incisional hernia prevention in septic patients undergoing laparoscopy

    https://ftp.medi-paper.com/wp-content/uploads/2018/12/TIGR®Matrix-shows-promising-results-when-used-for-incisional-hernia-prevention-in-septic-patients-undergoing-laparoscopy.jpg 1000 1500 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-12-04 21:28:362018-12-05 11:50:08TIGR®Matrix shows promising results when used for incisional hernia prevention in septic patients undergoing laparoscopy
    Efficacy of Oral Cladribine in Multiple Sclerosis Durable after a 2-Year Course of Treatment

    Efficacy of oral Cladribine for MS durable after a two-year treatment course

    https://ftp.medi-paper.com/wp-content/uploads/2018/12/Efficacy-of-Oral-Cladribine-in-Multiple-Sclerosis-Durable-after-a-2-Year-Course-of-Treatment.jpg 1000 1500 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-12-03 17:05:442018-12-03 17:21:47Efficacy of oral Cladribine for MS durable after a two-year treatment course

    Gilteritinib (Xospata®) FDA approved for relapsed or refractory AML harbouring FLT3 mutations

    https://ftp.medi-paper.com/wp-content/uploads/2018/11/1542721242_FDA-Logo-2018-MediPR-Medi-Paper-MediPaper-Medical-Communications-Ltd.-.png 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-11-29 15:08:432018-11-29 15:11:38Gilteritinib (Xospata®) FDA approved for relapsed or refractory AML harbouring FLT3 mutations

    TKR inhibitor larotrectinib (Vitrakvi®) FDA approved for cancers with NTRK gene fusion

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    FDA Approves Truxima as Biosimilar to Rituxan

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    Meta-analysis: TIVA with propofol lowers post-operative nausea, vomiting, and pain

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    Venetoclax plus azacitidine, decitabine, or low-dose cytarabine FDA approved in elderly AML patients

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    Glasdegib plus low-dose cytarabine (LDAC) approved in elderly AML patients

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    The Emerging Role of Yttrium-90 in Primary and Metastatic Liver Cancer

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    Intraperitoneal bupivacaine to reduce postoperative opioid-use following laparoscopic appendectomy

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    Emapalumab FDA approved in adult and paediatric patients with primary hemophagocytic lymphohistiocytosis

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    Brentuximab vedotin (Adcetris®) plus chemotherapy approved for several CD30 expressing lymphomas

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    Fully resorbable synthetic matrix offers improved safety for breast cancer patients undergoing immediate breast reconstruction

    Fully resorbable synthetic matrix offers improved safety for breast cancer patients undergoing immediate breast reconstruction

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    Pembrolizumab FDA approved in hepatocellular carcinoma patients pretreated with sorafenib

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    I-O in Special Populations: Chronic Viral Hepatitis Carriers

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    Lorlatinib FDA approved for metastatic ALK-positive NSCLC

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    ESMO 2018 HCC: The ESMO18 hepatobiliary cancer track summarised

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    Pembrolizumab plus chemotherapy approved for metastatic squamous NSCLC

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    Management of Immune-Mediated Hepatitis: a Case Report

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    Early treatment with ocrelizumab lowers 5-year brain atrophy-rates in MS

    Early treatment with ocrelizumab lowers 5-year brain atrophy rates in MS

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    PARPi talazoparib FDA approved for deleterious gBRCAm HER2‑negative breast cancer

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    Anti-PD1 sintilimab plus biosimilar bevacizumab receive IND-status by China NMPA

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    IMpower133 first-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer

    IMpower133: first-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer

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    Pembrolizumab plus chemotherapy effective in squamous NSCLC

    Pembrolizumab plus chemotherapy effective in squamous NSCLC

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    Ipilimumab plus nivolumab for persistent or recurrent ovarian cancer

    Ipilimumab plus nivolumab for persistent or recurrent ovarian cancer

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    Brigatinib prolongs PFS compared to crizotinib in ALK-Positive NSCLC

    Brigatinib prolongs PFS compared to crizotinib in ALK-Positive NSCLC

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    CAR-T axicabtagene ciloleucel granted Orphan Drug Designation for B-Cell Lymphoma by the Japan MHLW

    CAR-T axicabtagene ciloleucel granted Orphan Drug designation for B-Cell Lymphoma by the Japan MHLW

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    PD-1 mAB cemiplimab FDA approved for locally advanced and metastatic cutaneous squamous cell carcinoma (CSCC)

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    JAVELIN Lung 200 avelumab vs docetaxel in patients with pretreated advanced non-small cell lung cancer NSCLC

    JAVELIN Lung 200: avelumab vs docetaxel for pretreated NSCLC

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    Dacomitinib FDA approved for the first-line treatment of metastatic EGFR-mutated NSCLC

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    TAVR transcatheter aortic valve replacement with Portico valve reduces severe aortic stenosis in real-world study PORTICO-1

    Transcatheter aortic valve replacement reduces severe aortic stenosis in real-world study

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    TAVR vs SAVR - Transcatheter- vs surgical aortic valve replacement in high-risk patients 5-years survival

    Transcatheter- vs surgical aortic valve replacement in high-risk patients: 5-years survival

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    MediPr medipr.org medi-paper.com MediNews Asia MediNews.asia MediNews.cn MediPaper Medical Communications Ltd Healthcare Writers Medical Writers Medical Writer Agency Hong Kong Medical Writing Services Solutions Quote 醫學寫作 香港 醫學作家香港©United States Food and Drug Agency US FDA

    Duvelisib FDA approved for adult patients with R/R CLL or SLL

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    MediPr medipr.org medi-paper.com MediNews Asia MediNews.asia MediNews.cn MediPaper Medical Communications Ltd Healthcare Writers Medical Writers Medical Writer Agency Hong Kong Medical Writing Services Solutions Quote 醫學寫作 香港 醫學作家香港©United States Food and Drug Agency US FDA

    Duvelisib FDA approved for adult patients with R/R follicular lymphoma

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    Front-line atezolizumab plus chemotherapy improves PFS in NSCLC

    Frontline atezolizumab plus chemotherapy improves PFS in NSCLC

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    immuno-oncology I-O treatment for the irAE Rash©MediPaper Medical Communications Ltd

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    Prof Stefan Kasper on I-O in EXTREME-ineligible Head and Neck Cancer I-O in SCCHN with focus on EXTREME-ineligible Patients and the future directions of combination immunotherapy

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    MediPr medipr.org medi-paper.com MediNews Asia MediNews.asia MediNews.cn MediPaper Medical Communications Ltd Healthcare Writers Medical Writers Medical Writer Agency Hong Kong Medical Writing Services Solutions Quote 醫學寫作 香港 醫學作家香港©United States Food and Drug Agency US FDA

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    Adrian TSE HKIOC irAE pneumonitis lung immunotherapy-induced pneumonitis I-O Immuno-Oncology cannonball metastases cancer©MediPaper Medical Communications Ltd

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    https://ftp.medi-paper.com/wp-content/uploads/2017/11/Adrian-TSE-HKIOC-irAE-pneumonitis-lung-immunotherapy-induced-pneumonitis-I-O-Immuno-Oncology-cannonball-metastases-cancer.jpg 838 798 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-09-14 13:13:492018-09-21 13:56:54I-O in Special Populations: the Treatment of Immunotherapy-Induced Pneumonitis
    MediPr medipr.org medi-paper.com MediNews Asia MediNews.asia MediNews.cn MediPaper Medical Communications Ltd Healthcare Writers Medical Writers Medical Writer Agency Hong Kong Medical Writing Services Solutions Quote 醫學寫作 香港 醫學作家香港©United States Food and Drug Agency US FDA

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    Lung Cancer Capmatinib plus gefitinib promising in MET-dysregulated NSCLC MediPaper Medical Communications Medical Writer Hong Kong 醫學寫作 醫學作家香港© Eraxion / 123RF Stock Photo

    Capmatinib plus gefitinib promising in MET-dysregulated NSCLC

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    CAR-TCR Summit 2018 Preliminary first-in-human data with CAR-Claudin18.2-T in gastric and pancreatic cancer© Royaltystockphoto / 123RF Stock Photo

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    Blood-based TMB-assay predicts response to atezolizumab in NSCLC patients

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    Edoxaban in Asian patients with atrial fibrillation: effectiveness and safety

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    Pembrolizumab plus pemetrexed-platinum approved for use in the 1st-line treatment of metastatic non-squamous NSCLC

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    Talazoparib in advanced breast cancer patients with a germline BRCA1:2 mutation

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    CheckMate 032 Nivolumab ipilimumab metastatic esophagogastric cancer

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    Pembrolizumab plus pemetrexed-platinum approved for use in the 1st-line treatment of metastatic non-squamous NSCLC

    Lenvatinib FDA approved for 1st-line treatment of HCC

    https://ftp.medi-paper.com/wp-content/uploads/2018/08/FDA-approved-lenvatinib-capsules-Lenvima-Eisai-Inc.-for-1st-line-treatment-of-patients-with-unresectable-hepatocellular-carcinoma-HCC.-More-Information-.-August-16-2018-e1537925351885.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-08-18 15:50:342018-08-21 22:35:40Lenvatinib FDA approved for 1st-line treatment of HCC
    PolyU Researcher Develop Novel Self-fitting Scaffold for Bone-Regeneration©Polytech University Hong Kong

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    Pan-EGFR TKI pirotinib has commenced into Phase II clinical testing in China©Alex011973 / 123RF Stock Photo

    Pan-EGFR TKI pirotinib has commenced into Phase II clinical testing in China

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    FDA approved lusutrombopag (Mulpleta, Shionogi Inc.) for thrombocytopenia in adults with chronic liver disease who are scheduled to undergo a medical or dental procedure. More Information.  July 31, 2018.

    FDA approved mogamulizumab for adult patients with relapsed or refractory CTCL

    https://ftp.medi-paper.com/wp-content/uploads/2018/08/FDA-approved-lusutrombopag-Mulpleta-Shionogi-Inc.-for-thrombocytopenia-in-adults-with-chronic-liver-disease-who-are-scheduled-to-undergo-a-medical-or-dental-procedure.-More-Information.-July-31-2018-e1537925382959.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-08-09 00:58:382018-08-12 12:28:54FDA approved mogamulizumab for adult patients with relapsed or refractory CTCL
    FDA approved lusutrombopag (Mulpleta, Shionogi Inc.) for thrombocytopenia in adults with chronic liver disease who are scheduled to undergo a medical or dental procedure. More Information.  July 31, 2018.

    Lusutrombopag FDA approved for thrombocytopenia in adult chronic liver disease patients

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    Ribociclib FDA label updated to include pre- and perimenopausal women©United States Food and Drug Agency

    Iobenguane I-131 FDA approved for rare adrenal neuroendocrine tumours

    https://ftp.medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-31 15:44:032018-07-31 15:45:41Iobenguane I-131 FDA approved for rare adrenal neuroendocrine tumours
    T790M osimertinib nsclc brain metastasis CNS metastases Osimertinib in patients With T790M-Positive Advanced Non-Small-Cell Lung Cancer and brain metastases AURA3© srr283/123RF

    Osimertinib in patients with T790M-positive advanced non-small cell lung cancer and brain metastases (AURA3)

    https://ftp.medi-paper.com/wp-content/uploads/2018/08/T790M-osimertinib-nsclc-CNS-brain-metastasis-Osimertinib-in-patients-With-T790M-Positive-Advanced-Non-Small-Cell-Lung-Cancer-and-brain-metastases-AURA3.jpg 1000 1500 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-30 23:43:262018-08-20 12:36:41Osimertinib in patients with T790M-positive advanced non-small cell lung cancer and brain metastases (AURA3)

    Standard- and low-dose rivaroxaban in Asians with AF: Effectiveness and Safety

    https://ftp.medi-paper.com/wp-content/uploads/2018/08/cv1.jpg 1000 1500 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-30 09:51:512018-08-30 10:05:16Standard- and low-dose rivaroxaban in Asians with AF: Effectiveness and Safety
    Anti-PD1 with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma

    Anti-PD1 with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma

    https://ftp.medi-paper.com/wp-content/uploads/2018/08/Anti-PD1-with-Cemiplimab-in-Advanced-Cutaneous-Squamous-Cell-Carcinoma.jpg 1000 1500 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-26 23:44:412018-08-22 23:58:36Anti-PD1 with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma
    Ribociclib FDA label updated to include pre- and perimenopausal women©United States Food and Drug Agency

    Ivosidenib FDA approved for relapsed or refractory acute myeloid leukemia

    https://ftp.medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-23 11:33:402018-07-30 10:43:08Ivosidenib FDA approved for relapsed or refractory acute myeloid leukemia
    FDA approved enzalutamide (XTANDI, Astellas Pharma US, Inc.), for patients with castration-resistant prostate cancer (CRPC). More Information.  July 13, 2018

    Filgrastim-aafi FDA approved as Filgrastim Biosimilar

    https://ftp.medi-paper.com/wp-content/uploads/2018/07/FDA-approved-enzalutamide-XTANDI-Astellas-Pharma-US-Inc.-for-patients-with-castration-resistant-prostate-cancer-CRPC.-More-Information-.-July-13-2018-e1537925607982.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-20 10:58:232018-08-11 23:55:01Filgrastim-aafi FDA approved as Filgrastim Biosimilar
    Ribociclib FDA label updated to include pre- and perimenopausal women©United States Food and Drug Agency

    Ribociclib FDA label updated to include pre- and perimenopausal women

    https://ftp.medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-19 01:01:572018-07-30 10:42:22Ribociclib FDA label updated to include pre- and perimenopausal women
    FDA approved enzalutamide (XTANDI, Astellas Pharma US, Inc.), for patients with castration-resistant prostate cancer (CRPC). More Information.  July 13, 2018

    Enzalutamide FDA approved for castration-resistant prostate cancer (CRPC)

    https://ftp.medi-paper.com/wp-content/uploads/2018/07/FDA-approved-enzalutamide-XTANDI-Astellas-Pharma-US-Inc.-for-patients-with-castration-resistant-prostate-cancer-CRPC.-More-Information-.-July-13-2018-e1537925607982.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-17 10:14:112018-07-30 10:42:09Enzalutamide FDA approved for castration-resistant prostate cancer (CRPC)
    EBV pembrolizumab gastric cancer - MSI-H pembrolizumab gastric cancer - CPS pembrolizumab gastric cancer - MSI, EBV, CPS predict pembrolizumab outcome in gastric cancer© abhijith3747/123RF

    EBV, MSI, and CPS predict pembrolizumab outcome in gastric cancer

    https://ftp.medi-paper.com/wp-content/uploads/2018/08/EBV-pembrolizumab-gastric-cancer-MSI-H-pembrolizumab-gastric-cancer-CPS-pembrolizumab-gastric-cancer-MSI-EBV-CPS-predict-pembrolizumab-outcome-in-gastric-cancer.jpg 1000 1500 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-16 14:03:432018-08-31 08:15:52EBV, MSI, and CPS predict pembrolizumab outcome in gastric cancer
    Ribociclib FDA label updated to include pre- and perimenopausal women©United States Food and Drug Agency

    Ipilimumab plus nivolumab FDA approved for MSI-H and dMMR pre-treated mCRC

    https://ftp.medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-11 20:52:132018-07-30 10:41:58Ipilimumab plus nivolumab FDA approved for MSI-H and dMMR pre-treated mCRC
    Ribociclib FDA label updated to include pre- and perimenopausal women©United States Food and Drug Agency

    Combination encorafenib plus binimetinib for unresectable/metastatic BRAF V600E or V600K-positive melanoma FDA approved

    https://ftp.medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-07-02 22:14:052018-07-30 10:41:23Combination encorafenib plus binimetinib for unresectable/metastatic BRAF V600E or V600K-positive melanoma FDA approved
    ASCO 2018 nsclc immunotherapy ASCO18 lung cancer pembrolizumab avelumab nivolumab duravalumab ipilimumab osimertinib dacomitinib lorlatinib crizotinib alectinib keytruda KEYNOTE CheckMate JAVELIN IMpower©eraxion / 123RF Stock Photo

    ASCO 2018 NSCLC: The ASCO18 Lung Cancer Track Summarised

    https://ftp.medi-paper.com/wp-content/uploads/2018/06/ASCO-2018-nsclc-immunotherapy-ASCO18-lung-cancer-pembrolizumab-avelumab-nivolumab-duravalumab-ipilimumab-osimertinib-dacomitinib-lorlatinib-crizotinib-alectinib-keytruda-KEYNOTE-CheckMate-JAVELIN-IMpower.jpg 1000 1500 Anne John Michael https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Anne John Michael2018-06-25 18:22:252018-08-21 11:43:54ASCO 2018 NSCLC: The ASCO18 Lung Cancer Track Summarised
    FDA  has limited the use of Tecentriq and Keytruda for patients with locally advanced or metastatic urothelial cancer who are not eligible for cisplatin-containing therapy.  More Information.  June 19, 2018

    FDA limits use of atezolizumab and pembrolizumab in urothelial carcinoma

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    ASCO 2018 breast cancer TNBC MBC ABC ASCO18 PHEREXA D-CARE ABCSG-18 ASTRRA TEXT SOFT MONARCH-2 MONALEESA-3 SANDPIPER BOLERO-6 TOPACIO KEYNOTE-162 TONIC TOPACIO GeparNeuvo©eraxion / 123RF Stock Photo

    ASCO 2018 Breast Cancer: The ASCO18 breast cancer track summarised

    https://ftp.medi-paper.com/wp-content/uploads/2018/06/ASCO-2018-breast-cancer-TNBC-MBC-ABC-ASCO18-PHEREXA-D-CARE-ABCSG-18-ASTRRA-TEXT-SOFT-MONARCH-2-MONALEESA-3-SANDPIPER-BOLERO-6-TOPACIO-KEYNOTE-162-TONIC-TOPACIO-GeparNeuvo.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-06-19 09:02:512018-06-19 23:57:08ASCO 2018 Breast Cancer: The ASCO18 breast cancer track summarised
    Ribociclib FDA label updated to include pre- and perimenopausal women©United States Food and Drug Agency

    Bevacizumab in combination with carboplatin and paclitaxel FDA approved for several types of gynaecological cancers

    https://ftp.medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-06-14 22:56:042018-07-30 10:40:22Bevacizumab in combination with carboplatin and paclitaxel FDA approved for several types of gynaecological cancers
    Ribociclib FDA label updated to include pre- and perimenopausal women©United States Food and Drug Agency

    FDA approved pembrolizumab for 3rd-line PMBCL in adult and pediatric patients

    https://ftp.medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-06-14 22:42:142018-07-30 10:40:10FDA approved pembrolizumab for 3rd-line PMBCL in adult and pediatric patients
    Ribociclib FDA label updated to include pre- and perimenopausal women©United States Food and Drug Agency

    FDA approved pembrolizumab for chemotherapy-refractory r/m cervical cancer with PD-L1 CPS ≥1 

    https://ftp.medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-06-13 21:59:012018-07-30 10:39:54FDA approved pembrolizumab for chemotherapy-refractory r/m cervical cancer with PD-L1 CPS ≥1 
    ASCO18 ASCO 2018 HCC hepatocellular carcinoma liver cancer pembrolizumab KEYTRUDA atezolizumab TECENTRIQ PD-1 PD-L1 immunecheckpoint immunotherapy ramucirumab cabozantinib KEYNOTE-224 SCRUM-Japan GI-SCREEN CELESTIAL REACH-2© krishnacreations / 123RF Stock Photo

    ASCO 2018 HCC: The ASCO18 hepatocellular cancer track summarised

    https://ftp.medi-paper.com/wp-content/uploads/2018/06/ASCO18-ASCO-2018-HCC-hepatocellular-carcinoma-liver-cancer-pembrolizumab-KEYTRUDA-atezolizumab-TECENTRIQ-PD-1-PD-L1-immunecheckpoint-immunotherapy-ramucirumab-cabozantinib-KEYNOTE-224-SCRUM-Japan-GI-SCREEN-CELESTIAL-REACH-2.jpg 1000 1500 Anne John Michael https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Anne John Michael2018-06-10 11:59:542018-08-23 10:33:26ASCO 2018 HCC: The ASCO18 hepatocellular cancer track summarised
    Ribociclib FDA label updated to include pre- and perimenopausal women©United States Food and Drug Agency

    FDA approves venetoclax in 2nd-line for patients with CLL or SLL

    https://ftp.medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-06-09 11:25:082018-09-25 17:51:30FDA approves venetoclax in 2nd-line for patients with CLL or SLL
    Ribociclib FDA label updated to include pre- and perimenopausal women©United States Food and Drug Agency

    FDA approved biosimilar pegfilgrastim to decrease the chance of febrile neutropenia in patients with non-myeloid cancers on myelosuppressive chemotherapy

    https://ftp.medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-06-06 16:07:462018-08-11 23:55:46FDA approved biosimilar pegfilgrastim to decrease the chance of febrile neutropenia in patients with non-myeloid cancers on myelosuppressive chemotherapy
    IMPower150 Reck Socinski ELCC AACR 2018 firstline atezolizumab bevacizumab chemotherapy non-squamous nsclcbravajulia / 123RF Stock Photo

    AACR 2018: first-line atezolizumab, bevacizumab plus chemotherapy active in non-squamous NSCLC

    https://ftp.medi-paper.com/wp-content/uploads/2018/05/IMPower150-Reck-Socinski-ELCC-AACR-2018-firstline-atezolizumab-bevacizumab-chemotherapy-non-squamous-nsclc.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-05-10 16:19:462018-05-24 09:31:31AACR 2018: first-line atezolizumab, bevacizumab plus chemotherapy active in non-squamous NSCLC
    US FDA approved CAR-t cell BiTE DAR-T cell CD19 Immunotherapies blinatumomab axicabtagene ciloleucel tisagenlecleucel

    US FDA approved CAR-T cell and BiTE immunotherapy – Updated 2-May-2018

    https://ftp.medi-paper.com/wp-content/uploads/2018/04/US-FDA-approved-CAR-t-cell-BiTE-DAR-T-cell-CD19-Immunotherapies-blinatumomab-axicabtagene-ciloleucel-tisagenlecleucel.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-05-02 10:00:352018-05-24 09:36:21US FDA approved CAR-T cell and BiTE immunotherapy – Updated 2-May-2018
    Ribociclib FDA label updated to include pre- and perimenopausal women©United States Food and Drug Agency

    Adjuvant dabrafenib plus trametinib FDA approved for BRAF V600E or V600K melanoma

    https://ftp.medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-04-30 13:35:562018-07-30 11:42:21Adjuvant dabrafenib plus trametinib FDA approved for BRAF V600E or V600K melanoma
    AACR 2018 First-line Nivolumab-Ipilimumab in TMB-high NSCLC front-line immunotherapy for non-small cell lung cancer tumour-mutation burden CheckMate 227 NCT02477826Hywards / 123RF Stock Photo

    Nivolumab-Ipilimumab Combination: A New Option for TMB-High NSCLC (CheckMate 227)

    https://ftp.medi-paper.com/wp-content/uploads/2018/04/First-line-Nivolumab-Ipilimumab-in-TMB-high-NSCLC-front-line-immunotherapy-for-non-small-cell-lung-cancer-CheckMate-227-NCT02477826.jpg 1000 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-04-21 10:30:432018-05-24 09:37:03Nivolumab-Ipilimumab Combination: A New Option for TMB-High NSCLC (CheckMate 227)
    Ribociclib FDA label updated to include pre- and perimenopausal women©United States Food and Drug Agency

    FDA approved osimertinib for the 1st-line treatment of patients with EGFR exon 19 deletions or exon 21 L858R mutations positive metastatic non-small cell lung cancer (NSCLC)

    https://ftp.medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-04-19 13:36:062018-07-30 11:15:04FDA approved osimertinib for the 1st-line treatment of patients with EGFR exon 19 deletions or exon 21 L858R mutations positive metastatic non-small cell lung cancer (NSCLC)
    NCT02578680 Keynote189 AACR 2018 pembrolizumab chemotherapy nsclc NEJM Leena Gandhikrishnacreations / 123RF Stock Photo

    Frontline Combination of Pembrolizumab and Chemotherapy: A New Standard of Care for Non-squamous NSCLC

    https://ftp.medi-paper.com/wp-content/uploads/2018/04/NCT02578680-Keynote189-pembrolizumab-chemotherapy-nsclc-NEJM-Leena-Gandhi.jpg 938 1500 Stijn van den Borne, MSc https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png Stijn van den Borne, MSc2018-04-19 01:27:262018-05-24 09:37:16Frontline Combination of Pembrolizumab and Chemotherapy: A New Standard of Care for Non-squamous NSCLC
    Ribociclib FDA label updated to include pre- and perimenopausal women©United States Food and Drug Agency

    Frontline nivolumab plus ipilimumab approved for intermediate or poor risk advanced RCC

    https://ftp.medi-paper.com/wp-content/uploads/2018/06/us-fda-approval-medipaper-medical-communications-agency-medical-writer-agency-apac-asia-pacific-HK-hong-kong-oncology-CV-neurology-immunotherapy-obesity-diabetes-specialty-infectious-e1537925611846.jpg 1000 1495 News Feed https://medi-paper.com/wp-content/uploads/2020/02/MediPR-MediPaper-Medical-Communications-Ltd-Healthcare-Writers-Medical-Writers-Medical-Writer-Agency-Hong-Kong-Medical-Writing-Services-Solutions-Quote-醫學寫作-香港-醫學作家香港-medical-PR-public-relations-1030x374.png News Feed2018-04-16 13:59:012018-07-30 11:50:31Frontline nivolumab plus ipilimumab approved for intermediate or poor risk advanced RCC
    Keynote-042 Keynote-024 pembrolizumab nsclc keytruda nsclc non-squamous squamous PD-L1 expression 1% 20% 50% Tony Mok MD NCT02220894 Pembrolizumab effective in frontline NSCLC with low PD-L1 expression

    Pembrolizumab effective in frontline NSCLC with low PD-L1 expression

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    © Copyright 2018 MediPaper Medical Communications Ltd. – Immunotherapy & ImmunoOncology (I-O) – Nivolumab NPC Opdivo Nasopharyngeal Carcinoma Brigette Ma CUHK Phase II NCI-9742 study JCO Journal of Clinical Oncology 2018

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